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KMID : 0390020100200030162
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Pediatric Allergy and Respiratory Disease
2010 Volume.20 No. 3 p.162 ~ p.172
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Increased Vascular Endothelial Growth Factors in Nasopharyngeal Aspirates from Children with Acute RSV Bronchiolitis
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La Kyong-Suk
Nam Hyo-Kyoung
Siegfried Bauer
Kim Ji-Eun
Choi Ic-Sun
Lee Yoon
Yoo Young
Park Sang-Hee
Choung Ji-Tae
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Abstract
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Background:Viral infection is known as one of the dominant risk factors for wheezing in children hospitalized before 2 years of age. Although the major viral pathogen associated with wheezing is respiratory syncytial virus (RSV), the mechanisms of wheezing remain unclear. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and vascular permeability. The aim of this study was to evaluate the relationship between VEGF concentration and wheezing in children with acute RSV bronchiolitis.
Methods:Ninety-four children with acute bronchiolitis who were admitted to Korea University Anam Hospital were enrolled in this study. Based on the proven viral agents, children with bronchiolitis were divided into 2 groups: those who were infected with RSV (RSV (+) group, n=51) and those who were not (RSV (?) group, n=43). A complete history taking, physical examination and routine laboratory tests were performed on all children. VEGF levels in serum and nasopharyngeal aspirates (NPA) were determined by ELISA.
Results:NPA VEGF levels were significantly higher in the RSV (+) group than in the RSV (-) group (331.8±197.8 vs. 204.5±97.0 pg/mL, P =0.002). The duration of wheezing is significantly longer in the RSV (+) group than in the RSV (-) group (3.8±2.7 days vs. 2.4±1.8 days, P=0.037).
Conclusions:The results of this study suggest that children with RSV bronchiolitis may have significantly higher NPA VEGF levels than those without, which may be associated with a longer duration of wheezing in those with RSV bronchiolitis.
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KEYWORD
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Bronchiolitis, Children, RSV, Vascular endothelial growth factor, Wheezing
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